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</div> <div class="container-fluid clearfix layout_564394 text-center text-bold" style="font-size: 20px; color: rgb(0, 0, 0); margin-top: 30px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_439253"> <div class="column"> <div class="column visual-conent-title"> <p class="content-title"> 脂肪組織巨噬細胞分泌外泌體 miRNA可大幅改善體內胰島素敏感性</p> <div class="clearfix"> </div> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_610181" style="margin-top: 0px;"> <div class="column"> <div class="container clearfix layout_148235 text-center text-bold" style="font-size: 20px; color: rgb(0, 0, 0);"> <div class="column"> <div class="hr"> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_369638 text-center" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_13448"> <div class="column"> <div class="col-md-12 layout_455380"> <div class="col-md-2 column"> </div> <div class="col-md-8 column"> <div class="column visual-conent-author visual-inline-block"> <p class="content-author"> <span>作者：</span>admin</p> </div> <div class="column visual-conent-adddate visual-inline-block" style="padding-left: 15px; padding-right: 15px;"> <p class="content-adddate"> <span>添加時間：</span>2019-04-15 10:31:44</p> </div> <div class="column visual-conent-source visual-inline-block"> <p class="content-source"> <span>來源：</span>云序生物</p> </div> <div class="column visual-category-statistics visual-inline-block" style="padding-left: 15px;"> 瀏覽：<script src="/index.php?case=archive&act=view_js&aid=31"></script></div> </div> <div class="col-md-2 column"> </div> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_617573" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_903271"> <div class="column"> <div class="column visual-category-title"> <div class="content_tools_box"> <p class="content_tools"> <a href="javascript:CallPrint('print');">打印本文</a> <a href="javascript:doZoom(14)">小</a> <a href="javascript:doZoom(18)">中</a> <a href="javascript:doZoom(20)">大</a> </p> <div class="clearfix"> </div> </div> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_43304" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_784828"> <div class="column"> <div class="column visual-conent"> <p><strong>題目</strong>：<span style="color: rgb(25, 25, 25); font-family: "PingFang SC", Arial, 微軟雅黑, 宋體, simsun, sans-serif; background-color: rgb(255, 255, 255);">Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity</span></p><p><strong>期刊</strong>：Cell</p><p><strong>影響因子</strong>：30.410</p><p><strong>簡介</strong>：美國加州大學圣地亞哥分校Olefsky團隊和中國醫學科學院的研究者們，通過研究發現脂肪組織巨噬細胞（adipose tissue macrophages，ATMs）分泌的外泌體中含有miRNA并可以轉移到胰島素的靶細胞中，從而調節靶細胞對胰島素的敏感性以及體內的總糖代謝穩態。Olefsky團隊從肥胖小鼠脂肪組織內分離出巨噬細胞，再收集細胞里的外泌體，用它們處理體型瘦的健康小鼠，發現接受了外源外泌體的小鼠雖然體重依然正常，但卻出現肥胖誘導型胰島素抵抗癥狀。相反，提取瘦小鼠來源的脂肪組織巨噬細胞外泌體，并用它在肥胖小鼠上治療，會大幅改善體內和體外的葡萄糖耐受和胰島素敏感性。研究人員通過miRNA測序等方法，證明miR-155是肥胖個體脂肪組織巨噬細胞外泌體差異表達的miRNA之一，miR-155極有可能直接通過抑制其靶基因PPARγ來抑制胰島素信號傳導和葡萄糖耐受。</p><p style="text-align: center;"><img src="/html/upload/images/201904/15563513304722.png" title="15563513304722.png" alt="image.png"/></p></div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_676599" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_158624"> <div class="column"> <div class="hr"> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_667472"> <div class="column"> <div class="container clearfix layout_381979"> <div class="column"> <div class=" visual-conent-form"> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_886423" style="margin-top: 15px; margin-bottom: 5px;"> <div class="column"> <div class="container clearfix layout_390441"> <div class="column"> <div class="column visual-conent-page"> <div id="page"> <strong>上一篇</strong>無 <div class="blank10"> </div> <strong>下一篇</strong><a href="/index.php?case=archive&act=show&aid=32">大腦創傷外泌體中環狀RNA變化的研究</a> </div> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_402892" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_939884"> <div class="column"> <div class="hr"> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_57479" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_608164"> <div class="column"> <div class="column visual-conent-comment"> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_815628" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_771703"> <div class="column"> <div class="hr"> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_275539" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_875600"> <div class="column"> <div class="column visual-conent-relevant-list"> <h3> <a><a href='/index.php?case=tag&act=show&tag=%E5%A4%96%E6%B3%8C%E4%BD%93' target='_blank'>外泌體</a> <a href='/index.php?case=tag&act=show&tag=%E8%84%82%E8%82%AA%E7%BB%84%E7%BB%87' target='_blank'>脂肪組織</a> <small>相關內容</small></a> </h3> <span>——</span> <hr class="featurette-divider" /> <div class="container list-container"> <div class="news-list list-border list-border-w"> <div class="list-date"> <span>21</span> <p> 2019-03</p> </div> <h4> <a title=""新寵"外泌體正式進入臨床檢驗，路還有多遠？" href="/index.php?case=archive&act=show&aid=65" target="_blank">"新寵"外泌體正式進…</a> </h4> <p> 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