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</div> <div class="container-fluid clearfix layout_564394 text-center text-bold" style="font-size: 20px; color: rgb(0, 0, 0); margin-top: 30px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_439253"> <div class="column"> <div class="column visual-conent-title"> <p class="content-title"> 大腦創傷外泌體中環狀RNA變化的研究</p> <div class="clearfix"> </div> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_610181" style="margin-top: 0px;"> <div class="column"> <div class="container clearfix layout_148235 text-center text-bold" style="font-size: 20px; color: rgb(0, 0, 0);"> <div class="column"> <div class="hr"> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_369638 text-center" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_13448"> <div class="column"> <div class="col-md-12 layout_455380"> <div class="col-md-2 column"> </div> <div class="col-md-8 column"> <div class="column visual-conent-author visual-inline-block"> <p class="content-author"> <span>作者：</span>admin</p> </div> <div class="column visual-conent-adddate visual-inline-block" style="padding-left: 15px; padding-right: 15px;"> <p class="content-adddate"> <span>添加時間：</span>2019-04-15 13:22:22</p> </div> <div class="column visual-conent-source visual-inline-block"> <p class="content-source"> <span>來源：</span>云序生物</p> </div> <div class="column visual-category-statistics visual-inline-block" style="padding-left: 15px;"> 瀏覽：<script src="/index.php?case=archive&act=view_js&aid=32"></script></div> </div> <div class="col-md-2 column"> </div> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_617573" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_903271"> <div class="column"> <div class="column visual-category-title"> <div class="content_tools_box"> <p class="content_tools"> <a href="javascript:CallPrint('print');">打印本文</a> <a href="javascript:doZoom(14)">小</a> <a href="javascript:doZoom(18)">中</a> <a href="javascript:doZoom(20)">大</a> </p> <div class="clearfix"> </div> </div> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_43304" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_784828"> <div class="column"> <div class="column visual-conent"> <p><strong>題目</strong>：Circular RNA expression alteration in exosomes from the brain extracellular space after traumatic brain injury in mice</p><p><strong>期刊</strong>：Journal of Neurotrauma</p><p><strong>影響因子</strong>：5.19</p><p><strong>簡介</strong>：近期，天津醫科大學總醫院張建寧教授帶領的神經創傷團隊針對大腦創傷的研究。應用全轉錄組測序技術，僅通過大腦創傷外泌體中環狀RNA表達譜研究發表了世界首個小鼠腦創傷模型外泌體環狀RNA研究成果。作者首先分離了小鼠腦組織，提取腦周質外泌體，通過外泌體全轉錄組測序檢測TBI腦周組織外泌體中環狀RNA的表達變化。結果發現231個差異表達的環狀RNA，其中155個上調，76個下調。接下來通過生信分析如GO及KEGG分析對外泌體差異表達的環狀RNA進行了功能預測。GO分析表明這些RNA分子主要參與神經損傷修復，神經系統發育及神經信號傳導相關，這些分子同時主要富集在cGMP-PKG信號通路。環狀RNA-miRNA互作網絡圖揭示了環狀RNA作用靶miRNA及可能的功能。本文首次研究了大腦創傷外泌體中環狀RNA變化，為后續分子機理詳細研究提供諸多靶分子，也為大腦創傷的干預治療提供潛在的靶點。</p><p style="text-align: center;"><img src="/html/upload/images/201904/15563520612302.jpg" width="583" height="309"/></p><p style="text-align: center;"><img src="/html/upload/images/201904/15563520865966.jpg" width="529" height="330"/></p></div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_676599" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_158624"> <div class="column"> <div class="hr"> </div> </div> </div> </div> </div> <div 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href="/index.php?case=archive&act=show&aid=32" target="_blank">大腦創傷外泌體中環狀RNA變化的研究</a> </h4> <p> 近期，天津醫科大學總醫院張建寧教授帶領的神經創傷團隊針對大腦創傷的研究，應用全轉錄組測序技術，僅通過大腦創傷外泌體中環狀RNA表達譜研究發表了世界首個小鼠腦創傷模型外泌體環狀RNA研究成果?！?<a href="/index.php?case=archive&act=show&aid=32" target="_blank">[了解更多]</a> </p> </div> </div> <div class="clearfix"> </div> </div> </div> </div> </div> </div> </div> <div class="view-html"> <div class="container-fluid clearfix layout_971667" style="padding-top: 60px; padding-bottom: 60px; background-color: rgb(51, 51, 51); color: rgb(255, 255, 255);"> <div class="column"> <div class="container clearfix layout_976890 text-bold" style="font-size: 20px; padding-top: 20px; padding-bottom: 20px;"> <div class="column"> 廈門恩賽爾生物科技有限公司位于國家級企業孵化基地海滄生物醫藥產業園，參照GMP標準建設有完善的研發生產實驗室并通過廈門市食品藥品質量檢查研究院依據國家標準GB50457-2008的潔凈級別檢測，團隊匯聚大幫技術精湛的博士、碩士人員及外籍科學家，并由多名“千人計劃”專家作為技術顧問，同時兼具遺傳咨詢師、系統架構師、注冊審核員等各類人才，具備專業的科學研究和服務咨詢能力。 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