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</div> <div class="container-fluid clearfix layout_564394 text-center text-bold" style="font-size: 20px; color: rgb(0, 0, 0); margin-top: 30px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_439253"> <div class="column"> <div class="column visual-conent-title"> <p class="content-title"> 腫瘤缺氧環境促進外泌體癌癥LncRNA高表達</p> <div class="clearfix"> </div> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_610181" style="margin-top: 0px;"> <div class="column"> <div class="container clearfix layout_148235 text-center text-bold" style="font-size: 20px; color: rgb(0, 0, 0);"> <div class="column"> <div class="hr"> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_369638 text-center" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_13448"> <div class="column"> <div class="col-md-12 layout_455380"> <div class="col-md-2 column"> </div> <div class="col-md-8 column"> <div class="column visual-conent-author visual-inline-block"> <p class="content-author"> <span>作者：</span>admin</p> </div> <div class="column visual-conent-adddate visual-inline-block" style="padding-left: 15px; padding-right: 15px;"> <p class="content-adddate"> <span>添加時間：</span>2019-04-08 13:28:32</p> </div> <div class="column visual-conent-source visual-inline-block"> <p class="content-source"> <span>來源：</span>云序生物</p> </div> <div class="column visual-category-statistics visual-inline-block" style="padding-left: 15px;"> 瀏覽：<script src="/index.php?case=archive&act=view_js&aid=34"></script></div> </div> <div class="col-md-2 column"> </div> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_617573" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_903271"> <div class="column"> <div class="column visual-category-title"> <div class="content_tools_box"> <p class="content_tools"> <a href="javascript:CallPrint('print');">打印本文</a> <a href="javascript:doZoom(14)">小</a> <a href="javascript:doZoom(18)">中</a> <a href="javascript:doZoom(20)">大</a> </p> <div class="clearfix"> </div> </div> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_43304" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_784828"> <div class="column"> <div class="column visual-conent"> <p><strong>題目</strong>：Hypoxic exosomes facilitate bladder tumor growth and development through transferring long non-coding RNA-UCA1</p><p><strong>期刊</strong>：Molecular Cell</p><p><strong>影響因子</strong>：7.78</p><p><strong>簡介</strong>：為克服實體腫瘤的惡性缺氧微環境，腫瘤細胞會分泌大量含非編碼RNA的外泌體，促進腫瘤的發生和轉移。研究人員選取膀胱癌5637細胞系作為實驗供體組，其具有LncRNA-UCA1（尿路上皮癌相關1型LncRNA）高表達的特點；膀胱癌UMUC2細胞系作為實驗受體組，其具有LncRNA-UCA1低表達的特點。通過透射電子顯微鏡、納米粒子跟蹤分析和蛋白質印跡分析分離并鑒定了在常氧及缺氧條件下5637細胞分泌的外泌體。將這些外泌體與UMUC2細胞共培養，發現來自5637細胞分離的缺氧外泌體會促進UMUC2細胞增殖、遷移和侵襲。與常氧狀態培養分離外泌體相比，5637細胞系的缺氧外泌體中LncRNA-UCA1表達水平較高。此外，缺氧外泌體LncRNA-UCA1可以在體外和體內通過上皮間質轉化促進腫瘤生殖生長。除此之外，膀胱癌患者血清外泌體中LncRNA-UCA1的表達水平顯著高于健康對照組。本文證實缺氧膀胱癌細胞通過分泌富含致癌性LncRNA-UCA1的外泌體到腫瘤微環境中，促進腫瘤的生長和發育。并且，人血清外泌體LncRNA-UCA1具有作為膀胱癌診斷生物標志物的可能性。</p><p style="text-align: center;"><img src="/html/upload/images/201904/15563526289517.png" width="833" height="679"/></p></div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_676599" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_158624"> <div class="column"> <div class="hr"> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_667472"> 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15px;"> <div class="column"> <div class="container clearfix layout_608164"> <div class="column"> <div class="column visual-conent-comment"> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_815628" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_771703"> <div class="column"> <div class="hr"> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_275539" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_875600"> <div class="column"> <div class="column visual-conent-relevant-list"> <h3> <a><small>相關內容</small></a> </h3> <span>——</span> <hr class="featurette-divider" /> <div class="container list-container"> <div class="news-list list-border list-border-w"> <div class="list-date"> <span>08</span> <p> 2019-04</p> </div> <h4> <a title="腫瘤缺氧環境促進外泌體癌癥LncRNA高表達" href="/index.php?case=archive&act=show&aid=34" target="_blank">腫瘤缺氧環境促進外泌體癌癥LncRNA高</a> </h4> <p> 本文證實缺氧膀胱癌細胞通過分泌富含致癌性LncRNA-UCA1的外泌體到腫瘤微環境中，促進腫瘤的生長和發育。并且，人血清外泌體LncRNA-UCA1具有作為膀胱癌診斷生物標志物的可能性?！?<a href="/index.php?case=archive&act=show&aid=34" target="_blank">[了解更多]</a> </p> </div> </div> <div class="clearfix"> </div> </div> </div> </div> </div> </div> </div> <div class="view-html"> <div class="container-fluid clearfix layout_971667" style="padding-top: 60px; padding-bottom: 60px; background-color: rgb(51, 51, 51); color: rgb(255, 255, 255);"> <div class="column"> <div class="container clearfix layout_976890 text-bold" style="font-size: 20px; padding-top: 20px; padding-bottom: 20px;"> <div class="column"> 廈門恩賽爾生物科技有限公司位于國家級企業孵化基地海滄生物醫藥產業園，參照GMP標準建設有完善的研發生產實驗室并通過廈門市食品藥品質量檢查研究院依據國家標準GB50457-2008的潔凈級別檢測，團隊匯聚大幫技術精湛的博士、碩士人員及外籍科學家，并由多名“千人計劃”專家作為技術顧問，同時兼具遺傳咨詢師、系統架構師、注冊審核員等各類人才，具備專業的科學研究和服務咨詢能力。 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